Disruption of Bcr-Abl Coiled Coil Oligomerization by Design

Oligomerization is an important regulatory mechanism for many proteins, including oncoproteins and other pathogenic proteins. The oncoprotein Bcr-Abl relies on oligomerization via its coiled coil domain for its kinase activity, suggesting that a designed coiled coil domain with enhanced binding to B...

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Bibliografiske detaljer
Main Authors: Dixon, Andrew S., Pendley, Scott S., Bruno, Benjamin J., Woessner, David W., Shimpi, Adrian A., Cheatham, Thomas E., Lim, Carol S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149365/
https://ncbi.nlm.nih.gov/pubmed/21659527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.264903
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