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Disrupting BCR-ABL in Combination with Secondary Leukemia-Specific Pathways in CML Cells Leads to Enhanced Apoptosis and Decreased Proliferation

Chronic myeloid leukemia (CML) is a myeloproliferative disorder caused by expression of the fusion gene BCR-ABL following a chromosomal translocation in the hematopoietic stem cell.(1) Therapeutic management of CML uses tyrosine kinase inhibitors (TKIs), which blocks ABL-signaling and effectively ki...

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Detalhes bibliográficos
Main Authors: Woessner, David W., Lim, Carol S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3604893/
https://ncbi.nlm.nih.gov/pubmed/23211037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp300405n
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