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Disruption of Bcr-Abl Coiled Coil Oligomerization by Design
Oligomerization is an important regulatory mechanism for many proteins, including oncoproteins and other pathogenic proteins. The oncoprotein Bcr-Abl relies on oligomerization via its coiled coil domain for its kinase activity, suggesting that a designed coiled coil domain with enhanced binding to B...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3149365/ https://ncbi.nlm.nih.gov/pubmed/21659527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.264903 |
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