Engineered Bivalent Ligands to Bias ErbB Receptor-mediated Signaling and Phenotypes

The ErbB receptor family is dysregulated in many cancers, and its therapeutic manipulation by targeted antibodies and kinase inhibitors has resulted in effective chemotherapies. However, many malignancies remain refractory to current interventions. We describe a new approach that directs ErbB recept...

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Detaylı Bibliyografya
Asıl Yazarlar: Jay, Steven M., Kurtagic, Elma, Alvarez, Luis M., de Picciotto, Seymour, Sanchez, Edgar, Hawkins, Jessica F., Prince, Robin N., Guerrero, Yadir, Treasure, Carolyn L., Lee, Richard T., Griffith, Linda G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2011
Konular:
Molecular Bases of Disease
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149363/
https://ncbi.nlm.nih.gov/pubmed/21622572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.221093
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