Bivalence of EGF-like ligands drives the ErbB signaling network.

Signaling by epidermal growth factor (EGF)-like ligands is mediated by an interactive network of four ErbB receptor tyrosine kinases, whose mechanism of ligand-induced dimerization is unknown. We contrasted two existing models: a conformation-driven activation of a receptor-intrinsic dimerization si...

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Detalhes bibliográficos
Main Authors: Tzahar, E, Pinkas-Kramarski, R, Moyer, J D, Klapper, L N, Alroy, I, Levkowitz, G, Shelly, M, Henis, S, Eisenstein, M, Ratzkin, B J, Sela, M, Andrews, G C, Yarden, Y
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170129/
https://ncbi.nlm.nih.gov/pubmed/9305636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.16.4938
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