Engineered Bivalent Ligands to Bias ErbB Receptor-mediated Signaling and Phenotypes

The ErbB receptor family is dysregulated in many cancers, and its therapeutic manipulation by targeted antibodies and kinase inhibitors has resulted in effective chemotherapies. However, many malignancies remain refractory to current interventions. We describe a new approach that directs ErbB recept...

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Detalhes bibliográficos
Main Authors: Jay, Steven M., Kurtagic, Elma, Alvarez, Luis M., de Picciotto, Seymour, Sanchez, Edgar, Hawkins, Jessica F., Prince, Robin N., Guerrero, Yadir, Treasure, Carolyn L., Lee, Richard T., Griffith, Linda G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149363/
https://ncbi.nlm.nih.gov/pubmed/21622572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.221093
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