Kinetics of Doubletime Kinase-dependent Degradation of the Drosophila Period Protein

Robust circadian oscillations of the proteins PERIOD (PER) and TIMELESS (TIM) are hallmarks of a functional clock in the fruit fly Drosophila melanogaster. Early morning phosphorylation of PER by the kinase Doubletime (DBT) and subsequent PER turnover is an essential step in the functioning of the D...

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Bibliographic Details
Main Authors: Syed, Sheyum, Saez, Lino, Young, Michael W.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149356/
https://ncbi.nlm.nih.gov/pubmed/21659538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.243618
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