Soluble Oligomers of Amyloid-β Peptide Disrupt Membrane Trafficking of α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor Contributing to Early Synapse Dysfunction

β-Amyloid (Aβ), a peptide generated from the amyloid precursor protein, is widely believed to underlie the pathophysiology of Alzheimer disease (AD). Emerging evidences suggest that soluble Aβ oligomers adversely affect synaptic function, leading to cognitive failure associated with AD. The Aβ-induc...

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Autors principals: Miñano-Molina, Alfredo J., España, Judit, Martín, Elsa, Barneda-Zahonero, Bruna, Fadó, Rut, Solé, Montse, Trullás, Ramón, Saura, Carlos A., Rodríguez-Alvarez, José
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Neurobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149325/
https://ncbi.nlm.nih.gov/pubmed/21665950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.227504
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