Soluble Oligomers of Amyloid-β Peptide Disrupt Membrane Trafficking of α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor Contributing to Early Synapse Dysfunction

β-Amyloid (Aβ), a peptide generated from the amyloid precursor protein, is widely believed to underlie the pathophysiology of Alzheimer disease (AD). Emerging evidences suggest that soluble Aβ oligomers adversely affect synaptic function, leading to cognitive failure associated with AD. The Aβ-induc...

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Detalhes bibliográficos
Main Authors: Miñano-Molina, Alfredo J., España, Judit, Martín, Elsa, Barneda-Zahonero, Bruna, Fadó, Rut, Solé, Montse, Trullás, Ramón, Saura, Carlos A., Rodríguez-Alvarez, José
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149325/
https://ncbi.nlm.nih.gov/pubmed/21665950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.227504
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