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Evidence for Two Sites of Superoxide Production by Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex I)

Complex I (NADH-ubiquinone oxidoreductase) can form superoxide during forward electron flow (NADH-oxidizing) or, at sufficiently high protonmotive force, during reverse electron transport from the ubiquinone (Q) pool (NAD(+)-reducing). We designed an assay system to allow titration of the redox stat...

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Detalhes bibliográficos
Main Authors: Treberg, Jason R., Quinlan, Casey L., Brand, Martin D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149303/
https://ncbi.nlm.nih.gov/pubmed/21659507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.252502
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