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The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria

NADH:ubiquinone oxidoreductase (complex I) is a major source of reactive oxygen species in mitochondria and a significant contributor to cellular oxidative stress. Here, we describe the kinetic and molecular mechanism of superoxide production by complex I isolated from bovine heart mitochondria and...

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Autori principali: Kussmaul, Lothar, Hirst, Judy
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472492/
https://ncbi.nlm.nih.gov/pubmed/16682634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510977103
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