Comparative Genomic Integration Profiling of Sleeping Beauty Transposons Mobilized With High Efficacy From Integrase-defective Lentiviral Vectors in Primary Human Cells

It has been previously shown that integrase-defective HIV-1-based gene vectors can serve, with moderate efficiency, as substrate for DNA transposition by a transiently expressed Sleeping Beauty (SB) transposase. Here, we describe the enhanced gene transfer properties of a HIV-1/SB hybrid vector that...

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Bibliografiske detaljer
Main Authors: Moldt, Brian, Miskey, Csaba, Staunstrup, Nicklas Heine, Gogol-Döring, Andreas, Bak, Rasmus O, Sharma, Nynne, Mátés, Lajos, Izsvák, Zsuzsanna, Chen, Wei, Ivics, Zoltán, Mikkelsen, Jacob Giehm
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149173/
https://ncbi.nlm.nih.gov/pubmed/21468003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.47
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