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Hybrid Lentivirus-transposon Vectors With a Random Integration Profile in Human Cells
Gene delivery by human immunodeficiency virus type 1 (HIV-1)-based lentiviral vectors (LVs) is efficient, but genomic integration of the viral DNA is strongly biased toward transcriptionally active loci resulting in an increased risk of insertional mutagenesis in gene therapy protocols. Nonviral Sle...
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Main Authors: | , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2835219/ https://ncbi.nlm.nih.gov/pubmed/19240688 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.10 |
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