Hybrid Lentivirus-transposon Vectors With a Random Integration Profile in Human Cells

Gene delivery by human immunodeficiency virus type 1 (HIV-1)-based lentiviral vectors (LVs) is efficient, but genomic integration of the viral DNA is strongly biased toward transcriptionally active loci resulting in an increased risk of insertional mutagenesis in gene therapy protocols. Nonviral Sle...

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Autors principals: Staunstrup, Nicklas H, Moldt, Brian, Mátés, Lajos, Villesen, Palle, Jakobsen, Maria, Ivics, Zoltán, Izsvák, Zsuzsanna, Mikkelsen, Jacob Giehm
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2009
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835219/
https://ncbi.nlm.nih.gov/pubmed/19240688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.10
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