Correct Interpretation of Comprehensive Phosphorylation Dynamics Requires Normalization by Protein Expression Changes

The interpretation of quantitative phosphoproteomics studies is complicated because each differential phosphorylation event integrates both changes in protein expression and phosphorylation. Here we investigated this phenomenon by performing parallel comparisons of protein expression and phosphoryla...

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Autores principales: Wu, Ronghu, Dephoure, Noah, Haas, Wilhelm, Huttlin, Edward L., Zhai, Bo, Sowa, Mathew E., Gygi, Steven P.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2011
Materias:
Technological Innovation and Resources
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149096/
https://ncbi.nlm.nih.gov/pubmed/21551504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M111.009654
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