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Promoter Hypomethylation Results in Increased Expression of Protein Phosphatase 2A in T Cells from Patients with Systemic Lupus Erythematosus

The catalytic subunit α isoform of protein phosphatase 2A (PP2Acα) activity, protein, and mRNA have been found increased in systemic lupus erythematosus (SLE) T cells and to contribute to decreased IL-2 production. The PP2Acα promoter activity is controlled epigenetically through the methylation of...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Sunahori, Katsue, Juang, Yuang-Taung, Kyttaris, Vasileios C., Tsokos, George C.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148941/
https://ncbi.nlm.nih.gov/pubmed/21346232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000340
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