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Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease
Huntington disease (HD) is a devastating neurodegenerative disorder for which there are no disease-modifying treatments. Previous studies have proposed that activation of the heat shock response (HSR) via the transcription factor heat shock factor 1 (HSF1) may be of therapeutic benefit. However, the...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3148745/ https://ncbi.nlm.nih.gov/pubmed/21785217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI57413 |
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