Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

Huntington disease (HD) is a devastating neurodegenerative disorder for which there are no disease-modifying treatments. Previous studies have proposed that activation of the heat shock response (HSR) via the transcription factor heat shock factor 1 (HSF1) may be of therapeutic benefit. However, the...

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Détails bibliographiques
Auteurs principaux: Labbadia, John, Cunliffe, Helen, Weiss, Andreas, Katsyuba, Elena, Sathasivam, Kirupa, Seredenina, Tamara, Woodman, Ben, Moussaoui, Saliha, Frentzel, Stefan, Luthi-Carter, Ruth, Paganetti, Paolo, Bates, Gillian P.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148745/
https://ncbi.nlm.nih.gov/pubmed/21785217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI57413
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