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Mice lacking microRNA 133a develop dynamin 2–dependent centronuclear myopathy
MicroRNAs modulate cellular phenotypes by inhibiting expression of mRNA targets. In this study, we have shown that the muscle-specific microRNAs miR-133a-1 and miR-133a-2 are essential for multiple facets of skeletal muscle function and homeostasis in mice. Mice with genetic deletions of miR-133a-1...
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| Главные авторы: | , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3148737/ https://ncbi.nlm.nih.gov/pubmed/21737882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI46267 |
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