Mice lacking microRNA 133a develop dynamin 2–dependent centronuclear myopathy

MicroRNAs modulate cellular phenotypes by inhibiting expression of mRNA targets. In this study, we have shown that the muscle-specific microRNAs miR-133a-1 and miR-133a-2 are essential for multiple facets of skeletal muscle function and homeostasis in mice. Mice with genetic deletions of miR-133a-1...

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Hlavní autoři: Liu, Ning, Bezprozvannaya, Svetlana, Shelton, John M., Frisard, Madlyn I., Hulver, Matthew W., McMillan, Ryan P., Wu, Yaru, Voelker, Kevin A., Grange, Robert W., Richardson, James A., Bassel-Duby, Rhonda, Olson, Eric N.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148737/
https://ncbi.nlm.nih.gov/pubmed/21737882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI46267
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