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Total Synthesis of Pumiliotoxins 209F and 251D via Late-Stage, Nickel-Catalyzed Epoxide-Alkyne Reductive Cyclization

[Image: see text] Pumiliotoxins 209F and 251D were synthesized using highly selective nickel-catalyzed epoxide-alkyne reductive cyclizations as the final step. The exocyclic (Z)-alkene found in the majority of the pumiliotoxins was formed stereospecifically and regioselectively, without the use of a...

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Detalhes bibliográficos
Main Authors: Woodin, Katrina S., Jamison, Timothy F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148183/
https://ncbi.nlm.nih.gov/pubmed/17696401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo071132e
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