MiR-17/20/93/106 promote hematopoietic cell expansion by targeting sequestosome 1–regulated pathways in mice

MicroRNAs (miRNAs) are pivotal for regulation of hematopoiesis but their critical targets remain largely unknown. Here, we show that ectopic expression of miR-17, -20,-93 and -106, all AAAGUGC seed-containing miRNAs, increases proliferation, colony outgrowth and replating capacity of myeloid progeni...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Meenhuis, Annemarie, van Veelen, Peter A., de Looper, Hans, van Boxtel, Nicole, van den Berge, Iris J., Sun, Su M., Taskesen, Erdogan, Stern, Patrick, de Ru, Arnoud H., van Adrichem, Arjan J., Demmers, Jeroen, Jongen-Lavrencic, Mojca, Löwenberg, Bob, Touw, Ivo P., Sharp, Phillip A., Erkeland, Stefan J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2011
Pynciau:
Hematopoiesis and Stem Cells
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148171/
https://ncbi.nlm.nih.gov/pubmed/21628417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-02-336487
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