MiR-17/20/93/106 promote hematopoietic cell expansion by targeting sequestosome 1–regulated pathways in mice

MicroRNAs (miRNAs) are pivotal for regulation of hematopoiesis but their critical targets remain largely unknown. Here, we show that ectopic expression of miR-17, -20,-93 and -106, all AAAGUGC seed-containing miRNAs, increases proliferation, colony outgrowth and replating capacity of myeloid progeni...

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Detalhes bibliográficos
Main Authors: Meenhuis, Annemarie, van Veelen, Peter A., de Looper, Hans, van Boxtel, Nicole, van den Berge, Iris J., Sun, Su M., Taskesen, Erdogan, Stern, Patrick, de Ru, Arnoud H., van Adrichem, Arjan J., Demmers, Jeroen, Jongen-Lavrencic, Mojca, Löwenberg, Bob, Touw, Ivo P., Sharp, Phillip A., Erkeland, Stefan J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148171/
https://ncbi.nlm.nih.gov/pubmed/21628417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-02-336487
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