Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner

Increased reactive oxygen species levels in the mitochondrial matrix can induce Parkin-dependent mitophagy, which selectively degrades dysfunctional mitochondria via the autolysosome pathway. Phosphorylated mitofusin-2 (MFN2), a receptor of parkin RBR E3 ubiquitin-protein ligase (Parkin), interacts...

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Pubblicato in:Cell Death Dis
Autori principali: Zhang, Cheng, Nie, Pengqing, Zhou, Chunliu, Hu, Yue, Duan, Suling, Gu, Meijia, Jiang, Dongxu, Wang, Yunfu, Deng, Zixin, Chen, Jincao, Chen, Shi, Wang, Lianrong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904769/
https://ncbi.nlm.nih.gov/pubmed/33627622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03484-3
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