CalDAG-GEFI deficiency protects mice in a novel model of FcγRIIA-mediated thrombosis and thrombocytopenia

Platelet activation via Fcγ receptor IIA (FcγRIIA) is a critical event in immune-mediated thrombocytopenia and thrombosis syndromes (ITT). We recently identified signaling by the guanine nucleotide exchange factor CalDAG-GEFI and the adenosine diphosphate receptor P2Y12 as independent pathways leadi...

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Bibliographische Detailangaben
Hauptverfasser: Stolla, Moritz, Stefanini, Lucia, André, Pierrette, Ouellette, Timothy D., Reilly, Michael P., McKenzie, Steven E., Bergmeier, Wolfgang
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2011
Schlagworte:
Thrombosis and Hemostasis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148161/
https://ncbi.nlm.nih.gov/pubmed/21652673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-342352
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