Highly Pathogenic Avian Influenza Viruses Do Not Inhibit Interferon Synthesis in Infected Chickens but Can Override the Interferon-Induced Antiviral State

From infection studies with cultured chicken cells and experimental mammalian hosts, it is well known that influenza viruses use the nonstructural protein 1 (NS1) to suppress the synthesis of interferon (IFN). However, our current knowledge regarding the in vivo role of virus-encoded NS1 in chickens...

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Detalhes bibliográficos
Main Authors: Penski, Nicola, Härtle, Sonja, Rubbenstroth, Dennis, Krohmann, Carsten, Ruggli, Nicolas, Schusser, Benjamin, Pfann, Michael, Reuter, Antje, Gohrbandt, Sandra, Hundt, Jana, Veits, Jutta, Breithaupt, Angele, Kochs, Georg, Stech, Jürgen, Summerfield, Artur, Vahlenkamp, Thomas, Kaspers, Bernd, Staeheli, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147912/
https://ncbi.nlm.nih.gov/pubmed/21613402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00063-11
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