Characteristic Resistance Mechanism of Mycobacterium tuberculosis to DC-159a, a New Respiratory Quinolone

A G88C mutation in GyrA is one of the key alterations by which Mycobacterium tuberculosis mutants acquire DC-159a resistance in vitro. A novel double mutation in GyrA, G88C D94H, conferred high DC-159a resistance. Different mutation patterns in GyrA were demonstrated for DC-159a-resistant mutants an...

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Bibliografiske detaljer
Main Authors: Sekiguchi, Jun-ichiro, Disratthakit, Areeya, Maeda, Shinji, Doi, Norio
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2011
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147633/
https://ncbi.nlm.nih.gov/pubmed/21555766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00417-10
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