Impact of the E540V Amino Acid Substitution in GyrB of Mycobacterium tuberculosis on Quinolone Resistance

Amino acid substitutions conferring resistance to quinolones in Mycobacterium tuberculosis have generally been found within the quinolone resistance-determining regions (QRDRs) in the A subunit of DNA gyrase (GyrA) rather than the B subunit of DNA gyrase (GyrB). To clarify the contribution of an ami...

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Bibliografiske detaljer
Main Authors: Kim, Hyun, Nakajima, Chie, Yokoyama, Kazumasa, Rahim, Zeaur, Kim, Youn Uck, Oguri, Hiroki, Suzuki, Yasuhiko
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2011
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147658/
https://ncbi.nlm.nih.gov/pubmed/21646485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00042-11
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