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Impact of the E540V Amino Acid Substitution in GyrB of Mycobacterium tuberculosis on Quinolone Resistance

Amino acid substitutions conferring resistance to quinolones in Mycobacterium tuberculosis have generally been found within the quinolone resistance-determining regions (QRDRs) in the A subunit of DNA gyrase (GyrA) rather than the B subunit of DNA gyrase (GyrB). To clarify the contribution of an ami...

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Bibliographische Detailangaben
Hauptverfasser: Kim, Hyun, Nakajima, Chie, Yokoyama, Kazumasa, Rahim, Zeaur, Kim, Youn Uck, Oguri, Hiroki, Suzuki, Yasuhiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147658/
https://ncbi.nlm.nih.gov/pubmed/21646485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00042-11
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