Antiviral Efficacy upon Administration of a HepDirect Prodrug of 2′-C-Methylcytidine to Hepatitis C Virus-Infected Chimpanzees

Hepatitis C virus (HCV) infects an estimated 170 million individuals worldwide, and the current standard of care, a combination of pegylated interferon alpha and ribavirin, is efficacious in achieving sustained viral response in ∼50% of treated patients. Novel therapies under investigation include t...

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Autors principals: Carroll, Steven S., Koeplinger, Kenneth, Vavrek, Marissa, Zhang, Nanyan Rena, Handt, Laurence, MacCoss, Malcolm, Olsen, David B., Reddy, K. Raja, Sun, Zhili, van Poelje, Paul D., Fujitaki, James M., Boyer, Serge H., Linemeyer, David L., Hecker, Scott J., Erion, Mark D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2011
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147631/
https://ncbi.nlm.nih.gov/pubmed/21628542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01152-10
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