Antiviral Efficacy upon Administration of a HepDirect Prodrug of 2′-C-Methylcytidine to Hepatitis C Virus-Infected Chimpanzees

Hepatitis C virus (HCV) infects an estimated 170 million individuals worldwide, and the current standard of care, a combination of pegylated interferon alpha and ribavirin, is efficacious in achieving sustained viral response in ∼50% of treated patients. Novel therapies under investigation include t...

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Главные авторы: Carroll, Steven S., Koeplinger, Kenneth, Vavrek, Marissa, Zhang, Nanyan Rena, Handt, Laurence, MacCoss, Malcolm, Olsen, David B., Reddy, K. Raja, Sun, Zhili, van Poelje, Paul D., Fujitaki, James M., Boyer, Serge H., Linemeyer, David L., Hecker, Scott J., Erion, Mark D.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2011
Предметы:
Antiviral Agents
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147631/
https://ncbi.nlm.nih.gov/pubmed/21628542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01152-10
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