Antiviral Efficacy upon Administration of a HepDirect Prodrug of 2′-C-Methylcytidine to Hepatitis C Virus-Infected Chimpanzees

Hepatitis C virus (HCV) infects an estimated 170 million individuals worldwide, and the current standard of care, a combination of pegylated interferon alpha and ribavirin, is efficacious in achieving sustained viral response in ∼50% of treated patients. Novel therapies under investigation include t...

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Bibliografiska uppgifter
Huvudupphovsmän: Carroll, Steven S., Koeplinger, Kenneth, Vavrek, Marissa, Zhang, Nanyan Rena, Handt, Laurence, MacCoss, Malcolm, Olsen, David B., Reddy, K. Raja, Sun, Zhili, van Poelje, Paul D., Fujitaki, James M., Boyer, Serge H., Linemeyer, David L., Hecker, Scott J., Erion, Mark D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2011
Ämnen:
Antiviral Agents
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147631/
https://ncbi.nlm.nih.gov/pubmed/21628542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01152-10
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