Pharmacokinetics, Pharmacodynamics, and Allometric Scaling of Chloroquine in a Murine Malaria Model

Chloroquine (CQ) is an important antimalarial drug for the treatment of special patient groups and as a comparator for preclinical testing of new drugs. Pharmacokinetic data for CQ in animal models are limited; thus, we conducted a three-part investigation, comprising (i) pharmacodynamic studies of...

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Bibliographic Details
Main Authors: Moore, Brioni R., Page-Sharp, Madhu, Stoney, Jillian R., Ilett, Kenneth F., Jago, Jeffrey D., Batty, Kevin T.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147625/
https://ncbi.nlm.nih.gov/pubmed/21646487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00067-11
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