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Multiplex Zymography Captures Stage-specific Activity Profiles of Cathepsins K, L, and S in Human Breast, Lung, and Cervical Cancer

BACKGROUND: Cathepsins K, L, and S are cysteine proteases upregulated in cancer and proteolyze extracellular matrix to facilitate metastasis, but difficulty distinguishing specific cathepsin activity in complex tissue extracts confounds scientific studies and employing them for use in clinical diagn...

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Detalhes bibliográficos
Main Authors: Chen, Binbin, Platt, Manu O
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3146840/
https://ncbi.nlm.nih.gov/pubmed/21756348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-9-109
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