Targeting the NG2/CSPG4 Proteoglycan Retards Tumour Growth and Angiogenesis in Preclinical Models of GBM and Melanoma

Aberrant expression of the progenitor marker Neuron-glia 2 (NG2/CSPG4) or melanoma proteoglycan on cancer cells and angiogenic vasculature is associated with an aggressive disease course in several malignancies including glioblastoma multiforme (GBM) and melanoma. Thus, we investigated the mechanism...

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Autors principals: Wang, Jian, Svendsen, Agnete, Kmiecik, Justyna, Immervoll, Heike, Skaftnesmo, Kai Ove, Planagumà, Jesús, Reed, Rolf Kåre, Bjerkvig, Rolf, Miletic, Hrvoje, Enger, Per Øyvind, Rygh, Cecilie Brekke, Chekenya, Martha
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3146530/
https://ncbi.nlm.nih.gov/pubmed/21829586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023062
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