Effects of Heparin and Enoxaparin on APP Processing and Aβ Production in Primary Cortical Neurons from Tg2576 Mice

BACKGROUND: Alzheimer's disease (AD) is caused by accumulation of Aβ, which is produced through sequential cleavage of β-amyloid precursor protein (APP) by the β-site APP cleaving enzyme (BACE1) and γ-secretase. Enoxaparin, a low molecular weight form of the glycosaminoglycan (GAG) heparin, has...

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Autors principals: Cui, Hao, Hung, Amos C., Klaver, David W., Suzuki, Toshiharu, Freeman, Craig, Narkowicz, Christian, Jacobson, Glenn A., Small, David H.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3146518/
https://ncbi.nlm.nih.gov/pubmed/21829577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023007
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