Extended safety and efficacy studies of a live attenuated double leucine and pantothenate auxotroph of Mycobacterium tuberculosis as a vaccine candidate

We have previously described the development of a live, fully attenuated Mycobacterium tuberculosis (Mtb) vaccine candidate strain with two independent attenuating auxotrophic mutations in leucine and pantothenate biosynthesis. In the present work, those studies have been extended to include testing...

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Autores principales: Sampson, Samantha L., Mansfield, Keith G., Carville, Angela, Magee, D. Mitchell, Quitugua, Teresa, Howerth, Elizabeth W., Bloom, Barry R., Hondalus, Mary K.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3146342/
https://ncbi.nlm.nih.gov/pubmed/21549795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2011.04.066
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