Protection Elicited by a Double Leucine and Pantothenate Auxotroph of Mycobacterium tuberculosis in Guinea Pigs

We developed a live, fully attenuated Mycobacterium tuberculosis vaccine candidate strain with two independent attenuating auxotrophic mutations in leucine and pantothenate biosynthesis. The ΔleuD ΔpanCD double auxotroph is fully attenuated in the SCID mouse model and highly immunogenic and protecti...

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Autori principali: Sampson, Samantha L., Dascher, Christopher C., Sambandamurthy, Vasan K., Russell, Robert G., Jacobs, William R., Bloom, Barry R., Hondalus, Mary K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
Soggetti:
Microbial Immunity and Vaccines
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC387862/
https://ncbi.nlm.nih.gov/pubmed/15102816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.5.3031-3037.2004
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