Protection Elicited by a Double Leucine and Pantothenate Auxotroph of Mycobacterium tuberculosis in Guinea Pigs

We developed a live, fully attenuated Mycobacterium tuberculosis vaccine candidate strain with two independent attenuating auxotrophic mutations in leucine and pantothenate biosynthesis. The ΔleuD ΔpanCD double auxotroph is fully attenuated in the SCID mouse model and highly immunogenic and protecti...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sampson, Samantha L., Dascher, Christopher C., Sambandamurthy, Vasan K., Russell, Robert G., Jacobs, William R., Bloom, Barry R., Hondalus, Mary K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2004
Pynciau:
Microbial Immunity and Vaccines
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC387862/
https://ncbi.nlm.nih.gov/pubmed/15102816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.5.3031-3037.2004
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