Protection Elicited by a Double Leucine and Pantothenate Auxotroph of Mycobacterium tuberculosis in Guinea Pigs

We developed a live, fully attenuated Mycobacterium tuberculosis vaccine candidate strain with two independent attenuating auxotrophic mutations in leucine and pantothenate biosynthesis. The ΔleuD ΔpanCD double auxotroph is fully attenuated in the SCID mouse model and highly immunogenic and protecti...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Sampson, Samantha L., Dascher, Christopher C., Sambandamurthy, Vasan K., Russell, Robert G., Jacobs, William R., Bloom, Barry R., Hondalus, Mary K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Microbial Immunity and Vaccines
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC387862/
https://ncbi.nlm.nih.gov/pubmed/15102816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.5.3031-3037.2004
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars