Protection Elicited by a Double Leucine and Pantothenate Auxotroph of Mycobacterium tuberculosis in Guinea Pigs

We developed a live, fully attenuated Mycobacterium tuberculosis vaccine candidate strain with two independent attenuating auxotrophic mutations in leucine and pantothenate biosynthesis. The ΔleuD ΔpanCD double auxotroph is fully attenuated in the SCID mouse model and highly immunogenic and protecti...

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Bibliographic Details
Main Authors: Sampson, Samantha L., Dascher, Christopher C., Sambandamurthy, Vasan K., Russell, Robert G., Jacobs, William R., Bloom, Barry R., Hondalus, Mary K.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC387862/
https://ncbi.nlm.nih.gov/pubmed/15102816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.5.3031-3037.2004
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