Extended safety and efficacy studies of a live attenuated double leucine and pantothenate auxotroph of Mycobacterium tuberculosis as a vaccine candidate

We have previously described the development of a live, fully attenuated Mycobacterium tuberculosis (Mtb) vaccine candidate strain with two independent attenuating auxotrophic mutations in leucine and pantothenate biosynthesis. In the present work, those studies have been extended to include testing...

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Detalhes bibliográficos
Main Authors: Sampson, Samantha L., Mansfield, Keith G., Carville, Angela, Magee, D. Mitchell, Quitugua, Teresa, Howerth, Elizabeth W., Bloom, Barry R., Hondalus, Mary K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3146342/
https://ncbi.nlm.nih.gov/pubmed/21549795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2011.04.066
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