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Cyclin A2 Mutagenesis Analysis: A New Insight into CDK Activation and Cellular Localization Requirements
Cyclin A2 is essential at two critical points in the somatic cell cycle: during S phase, when it activates CDK2, and during the G2 to M transition when it activates CDK1. Based on the crystal structure of Cyclin A2 in association with CDKs, we generated a panel of mutants to characterize the specifi...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3145769/ https://ncbi.nlm.nih.gov/pubmed/21829545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022879 |
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