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Cyclin A2 Mutagenesis Analysis: A New Insight into CDK Activation and Cellular Localization Requirements

Cyclin A2 is essential at two critical points in the somatic cell cycle: during S phase, when it activates CDK2, and during the G2 to M transition when it activates CDK1. Based on the crystal structure of Cyclin A2 in association with CDKs, we generated a panel of mutants to characterize the specifi...

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Detalhes bibliográficos
Main Authors: Bendris, Nawal, Lemmers, Bénédicte, Blanchard, Jean-Marie, Arsic, Nikola
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145769/
https://ncbi.nlm.nih.gov/pubmed/21829545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022879
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