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Centrosomal Localization of Cyclin E-Cdk2 is Required for Initiation of DNA Synthesis
Cyclin E-Cdk2 is known to regulate both DNA replication and centrosome duplication during the G1-S transition in the cell cycle [1–4], and disruption of centrosomes results in a G1 arrest in some cell types [5–7]. Localization of cyclin E on centrosomes is mediated by a 20 amino acid domain termed t...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2897751/ https://ncbi.nlm.nih.gov/pubmed/20399658 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2010.03.028 |
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