Stereospecific gating of functional motions in Pin1

Pin1 is a modular enzyme that accelerates the cis-trans isomerization of phosphorylated-Ser/Thr-Pro (pS/T-P) motifs found in numerous signaling proteins regulating cell growth and neuronal survival. We have used NMR to investigate the interaction of Pin1 with three related ligands that include a pS-...

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Bibliografiska uppgifter
Huvudupphovsmän: Namanja, Andrew T., Wang, Xiaodong J., Xu, Bailing, Mercedes-Camacho, Ana Y., Wilson, Kimberly A., Etzkorn, Felicia A., Peng, Jeffrey W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2011
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145719/
https://ncbi.nlm.nih.gov/pubmed/21746900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019382108
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