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Convergent synthesis of α-ketoamide inhibitors of Pin1
[Image: see text] A convergent synthesis of α-ketoamide inhibitors of Pin1 is described. An α-hydroxyorthothioester derivative of Ser was reacted directly with an amine synthon. The reaction was catalyzed by HgO and HgCl(2) to form α-hydroxyamide. Thus, hydrolysis and coupling were combined in one s...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2844255/ https://ncbi.nlm.nih.gov/pubmed/20102178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol9027013 |
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