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Kinetic Isotope Effects Support the Twisted Amide Mechanism of Pin1 Peptidyl-Prolyl Isomerase

The Pin1 peptidyl-prolyl isomerase (PPIase) catalyzes isomerization of pSer/pThr-Pro motifs in regulating the cell cycle. Peptide substrates, Ac–Phe–Phe–phosphoSer–Pro–Arg–p-nitroaniline, were synthesized in unlabeled form, and with deuterium labeled Ser-d(3) and Pro-d(7) amino acids. Kinetic data w...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Mercedes-Camacho, Ana Y., Mullins, Ashley B., Mason, Matthew D., Xu, Guoyan G., Mahoney, Brendan J., Wang, Xingsheng, Peng, Jeffrey W., Etzkorn, Felicia A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891376/
https://ncbi.nlm.nih.gov/pubmed/24116866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400700b
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