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Enzyme-linked enzyme binding assay for Pin1 WW domain ligands

Peptidyl prolyl cis-trans isomerase (PPIase) interacting with NIMA-1 (Pin1) catalyzes the cis-trans isomerization of pSer/pThr–Pro amide bonds. Pin1 is a two-domain protein that represents a promising target for the treatment of cancer. Both domains of Pin1 bind the pSer/pThr–Pro motif; PPIase enzym...

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Sonraí Bibleagrafaíochta
Main Authors: Mercedes-Camacho, Ana Y., Etzkorn, Felicia A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876714/
https://ncbi.nlm.nih.gov/pubmed/20230769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2010.03.018
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