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tRNA-dependent peptide bond formation by the transferase PacB in biosynthesis of the pacidamycin group of pentapeptidyl nucleoside antibiotics

Pacidamycins are a family of uridyl tetra/pentapeptide antibiotics with antipseudomonal activities through inhibition of the translocase MraY in bacterial cell wall assembly. The biosynthetic gene cluster for pacidamycins has recently been identified through genome mining of the producer Streptomyce...

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Detalhes bibliográficos
Main Authors: Zhang, Wenjun, Ntai, Ioanna, Kelleher, Neil L., Walsh, Christopher T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145694/
https://ncbi.nlm.nih.gov/pubmed/21746899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109539108
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