Pac13 is a Small, Monomeric Dehydratase that Mediates the Formation of the 3′‐Deoxy Nucleoside of Pacidamycins

The uridyl peptide antibiotics (UPAs), of which pacidamycin is a member, have a clinically unexploited mode of action and an unusual assembly. Perhaps the most striking feature of these molecules is the biosynthetically unique 3′‐deoxyuridine that they share. This moiety is generated by an unusual,...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Michailidou, Freideriki, Chung, Chun‐wa, Brown, Murray J. B., Bent, Andrew F., Naismith, James H., Leavens, William J., Lynn, Sean M., Sharma, Sunil V., Goss, Rebecca J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656905/
https://ncbi.nlm.nih.gov/pubmed/28786545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201705639
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