Systemic delivery of NEMO binding domain/IKKγ inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology

The activation of nuclear factor κB (NF-κB) contributes to muscle degeneration that results from dystrophin deficiency in human Duchenne muscular dystrophy (DMD) and in the mdx mouse. In dystrophic muscle, NF-κB participates in inflammation and failure of muscle regeneration. Peptides containing the...

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Détails bibliographiques
Auteurs principaux: Reay, Daniel P., Yang, Michele, Watchko, Jon F., Daood, Molly, O'Day, Terrence L., Rehman, Khaleel K., Guttridge, Denis C., Robbins, Paul D., Clemens, Paula R.
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145633/
https://ncbi.nlm.nih.gov/pubmed/21624467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2011.05.008
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