A laminopathic mutation disrupting lamin filament assembly causes disease-like phenotypes in Caenorhabditis elegans

Mutations in the human LMNA gene underlie many laminopathic diseases, including Emery-Dreifuss muscular dystrophy (EDMD); however, a mechanistic link between the effect of mutations on lamin filament assembly and disease phenotypes has not been established. We studied the ΔK46 Caenorhabditis elegans...

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Detaylı Bibliyografya
Asıl Yazarlar: Bank, Erin M., Ben-Harush, Kfir, Wiesel-Motiuk, Naama, Barkan, Rachel, Feinstein, Naomi, Lotan, Oren, Medalia, Ohad, Gruenbaum, Yosef
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Cell Biology 2011
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Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145547/
https://ncbi.nlm.nih.gov/pubmed/21653823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-01-0064
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