APC/C(Cdh1)-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage

Targeted protein destruction of critical cellular regulators during the G1 phase of the cell cycle is achieved by anaphase-promoting complex/cyclosome(Cdh1) (APC/C(Cdh1)), a multisubunit E3 ubiquitin ligase. Cells lacking Cdh1 have been shown to accumulate deoxyribonucleic acid (DNA) damage, suggest...

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Main Authors: Cotto-Rios, Xiomaris M., Jones, Mathew J.K., Busino, Luca, Pagano, Michele, Huang, Tony T.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3144416/
https://ncbi.nlm.nih.gov/pubmed/21768287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201101062
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